The Best of Chronology brings the four original games into one all-encompassing game featuring: Sports, History, Inventions & Discoveries, and Art & Entertainment.

Game play is similar to original game. Each player is building a time line of cards. A card contains an event and the year in which it occurred. Players start with just one card, which are then placed face up under their "Time lock." On his/her turn, a player rolls the dice to see which category he will have and then is read an event from the next card. The player must then indicate the position on his own time line where the card should be placed. If he's correct he takes possession of the card and places it above his Time lock (timeline) and he may stop or continue trying another card. If at any time a player does not correctly insert the card into the right place on their Time line, they lose all the cards they have accumulated this turn in order to keep cards permanently, players must end their turn with a correct answer. First player with 10 cards in the correct order in their Time line wins.