Dungeon Degenerates: Hand of Doom takes place in the Dark Fantasy Realm of the decaying Eastern Provinces of the Würstreich. Players take escaped criminal adventurers on unsavory missions through four distinct regions, each with their own monsters & encounters. As the players explore the Würstreich, danger levels rise continuously across the map. Players must complete their mission before the Hand of Doom descends on the board, unleashing evil magic on the land.

Dungeon Degenerates is a co-op game where players can form parties or split up throughout the game at will; there is no obligation to stick together. Game play is 1-3 hours based on mission. Dungeon Degenerates has an epic RPG campaign feel in an open world sandbox board game, and you bring your experience & items from previous missions. There are multiple missions & objectives of varying difficulty with multiple ways to approach each mission.

Dungeon Degenerates is set in a cohesive & fixed world with multiple distinct regions which feature unique encounters & thematic monsters. Encounters allow multiple interaction choices; you do not have to fight everyone you see. Play features an open experience system allowing for character customization with new skills. You are always in danger - the town is not an artificial safe zone - combat is dangerous. There are various modes of travel - players cooperate to choose their route & pace, or split up & fend for themselves. Dungeon Degenerates features streamlined combat with tactical depth; each player rolls dice only once on their turn, using standard 6-sided dice only. There are over 100 monsters with unique abilities & artwork.