Disney Villainous: Introduction to Evil features the same gameplay as Disney Villainous, but this game features only four villains instead of six — Maleficent, Captain Hook, Ursula and Prince John – in a version that features streamlined gameplay crafted to help first-time players.

In the game, each player takes control of a villain with its own villain deck, fate deck, player board, and 3D character. On a turn, you move your character to a different location on your player board, taking one or more of the actions visible on that space (often by playing cards from your hand), then refill your hand to four cards. Cards are allies, items, effects, conditions, and (for some characters) curses. You need to use your cards to fulfill your unique win condition, which sometimes involves overcoming the hero from your villain's particular Disney film.

Disney Villainous: Introduction to Evil was originally released to celebrate the 100th anniversary of Disney, with the initial box design featuring Ursula, lustrous movers, and platinum rainbow-foil packaging as well as a Disney100 sticker.