Cardline: Marvel is similar to Cardline: Animals — but with superheroes and other characters from the Marvel Comics universe! It is a card game played with approximately 100 cards. Both sides of each card depict a character and its name, while its weight, IQ and fighting ability are printed on only one side of the card. For each game, players decide before playing which of the three statistics they're comparing.

At the start of the game, each player places a number of character cards on the table in front of them with the characteristics hidden. One card is placed in the center of the table with its characteristics revealed. Players then take turns placing a card from their tableau in a row on the table; a player can place a card between any two other cards. After placing the card, the player reveals the characteristics on it. If the card was placed correctly – that is, with the particular characteristic in numerical order compared to all other cards on the table – the card stays in place; otherwise the card is removed from play and the player takes another card from the deck and adds it to their tableau.

The first player to get rid of all their cards by placing them correctly wins.